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Glucosamine Chondroitin MSM - Supports Joint Structure, Function, and Comfort, 120 caps , (Doctor's Best)
The Roles of Glucosamine and Chondroitin Sulfate in Joints
Articular cartilage is a connective tissue composed of specialized cells (chondrocytes) embedded in a matrix of protein fibers (mostly collagen) and clusters of complex proteoglycan molecules that consist of a protein core with numerous side chains. These side chains, chiefly chondroitin sulfate and keratin sulfate, are long polysaccharide molecules called glycosaminoglycans. Chondroitin sulfate (CS) and the other glycosaminoglycans strongly attract water due to the negative charges of their sulfate groups. These negative charges also repel each other, creating spaces between glycosaminoglycan side chains where water can enter. This combination of solid and liquid gives cartilage a compressible quality that allows it to function as a shock absorber for joints.- Science-based nutrition
- Dietary supplement
- Maintains healthy joints and connective tissue
Glucosamine is a fundamental building block for proteoglycans and glycosaminoglycans. Glucosamine sulfate (GS) helps to maintain joint health through its ability to both act as a component of and stimulate formation of cartilage glycosaminoglycans and the hyaluronic acid backbone essential for the formation of cartilage proteoglycans.
The Abundant Evidence Behind Glucosamine and Chondroitin Sulfate
Extensive joint health research over the past few decades has investigated the effects of glucosamine sulfate, chondroitin sulfate, or a combination of the two. A 2009 meta-analysis summarized results from 6 well-designed studies involving a total of 1,502 research participants. The authors of this meta-analysis were able to make some conclusions about the apparent effectiveness of long-term oral supplementation with CS or GS. Glucosamine sulfate at 1,500 mg daily over a period of at least 3 years and chondroitin sulfate at 800 mg daily over a period of at least 2 years both helped subjects maintain healthy knee cartilage structure. In a 2008 review of GS & CS used for joint support, the London physician who wrote it concludes that, “Glucosamine, chondroitin, and the combination of these two agents have stood the test of time.
Glucosamine sulfate is one of the most important—and thoroughly researched—dietary supplements for joint health ever developed. In addition to its potential to influence joint structure (and thus function), research also backs the ability of GS to influence joint comfort. In one such multicenter, randomized, double-blind, parallel-group study of 252 subjects, joint comfort in the knee was found to be higher in the glucosamine sulfate group than the placebo group. Similar studies of equal magnitude found that GS enhanced joint comfort. Key among findings from these types of studies is the reoccurring theme of a good safety profile for glucosamine sulfate; reported “side effects” of GS were essentially no different than placebo.- Glucosamine sulfate stimulates cells to create proteoglycans, one of the main building blocks of joint cartilage.
- By attracting large amounts of water to proteoglycan molecules, chondroitin sulfate nourishes and lubricates joints.
- Thousands of case studies have shown that MSM has many health benefits, including a soothing effect on joints and other body tissues.
Similar to glucosamine, chondroitin sulfate is known to influence the maintenance of healthy cartilage—in this case by acting on matrix metalloproteases (MMPs). Chondroitin sulfate has been shown to inhibit MMP-3 synthesis, which plays an important role in homeostasis of cartilage proteoglycans. Additionally, CS can downplay MMP-13 in chondrocytes, helping to maintain the integrity of articular cartilage matrix.
Clinical Trials Explore MSM’s Joint Action
Results from a randomized, double-blind, placebo-controlled pilot trial examining the effect of MSM supplementation on joint comfort in 50 men and women are promising. Subjects taking OptiMSM methylsulfonylmethane for 12 weeks experienced greater joint comfort than those taking placebo, suggesting potential for MSM as a joint support nutrient that warrants further investigation in larger clinical trials. MSM also produced statistically significant changes in urinary malondialdehyde, a marker of oxidative stress.
MSM has also been used in combination with glucosamine to study their impact on the health of joints. In one such study, a total of 118 subjects were randomized into one of four groups for 12 weeks: glucosamine (500 mg three times daily), MSM (500 mg three times daily), the combination of glucosamine and MSM, or a placebo treatment. Glucosamine alone and MSM alone were shown to enhance joint function, while the combination was found to be even more effective, by both subjective and objective measurements.
SUGGESTED USAGE
As a dietary supplement, take 2 capsules twice daily, with or without food.
Note: Glucosamine is obtained from the shells of shellfish.
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Glucosamine Chondroitin MSM - Supports Joint Structure, Function, and Comfort, 120 caps , (Doctor's Best)
| Supplement Facts | Serving Size: 2 capsules
Servings Per Container: 60 |  | | | %DV | | | Chloride (from glucosamine sulfate 2KCI) | 84 mg | † | | | Sodium (from chondroitin sulfate sodium) | 28 mg | † | | | Potassium (from glucosamine sulfate 2KCI) | 91 mg | † | | | Glucosamine sulfate 2KCI | 750 mg | † | | | Chondroitin sulfate (from chondroitin sulfate sodium) | 600 mg | † | | | Methylsulfonylmethane LIGNISUL MSM | 500 mg | † |  | | | †Daily Value not yet established. | |
Other Ingredients: Cellulose, magnesium stearate (vegetable source), gelatin capsule.
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Glucosamine Chondroitin MSM - Supports Joint Structure, Function, and Comfort, 120 caps , (Doctor's Best)
Editor's rating: 8 out of 10
User's rating:  100%  0%
USER'S OPINION
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Glucosamine Chondroitin MSM - Supports Joint Structure, Function, and Comfort, 120 caps , (Doctor's Best)
FAQ
Can someone who has kidney stones take Glucosamine/ Chondroitin/MSM?
Yes. In fact, recent new evidence suggests that glucosamine may help prevent kidney stones, although this hasn't been proven for certain yet.
How much potassium is there in the Doctor's Best Glucosamine/ Chondroitin/ MSM?
Approximately 180mg, if the total daily recommended amount is consumed. This amount is comparable to eating half a banana.
Is Chondroitin sodium-free?
No, it does contain a small amount of sodium. Sodium must be added during processing. Glucosamine/Chondroitin/MSM contains just 14mg of sodium per capsule.
GUARANTEE/SHIPPING INFORMATION
Glucosamine Chondroitin MSM - is shipped in a discrete, unmarked package. Orders are processed immediately and usually take about 3 to 5 working days to be received. We do ask that you try it for 2 to 3 weeks to feel the full effects. Any information received is used only for order processing and shipping purposes. Your information, such as e-mail address, will never be disclosed to a third party.
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Glucosamine Chondroitin MSM - Supports Joint Structure, Function, and Comfort, 120 caps , (Doctor's Best)
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